11/12/2023 0 Comments Nocturnal asthmaPharmacological therapy that blocks the melatonin MT2 receptor could inhibit the detrimental effects of melatonin on airways, added Haruka Sasaki, DDS, also with Tohoku University and first author of the paper. Short-acting beta agonists such as albuterol. “It also suggests MT2 as a possible target for future therapy.” Quick-relief medications (rescue medications) Taken as needed for rapid, short-term relief of symptoms used to prevent or treat an asthma attack. “Overall, I think this supports the cautious use of exogenous melatonin in those with asthma, especially nocturnal asthma,” said Dr. Jon Romeo, DO, chair of the American College of Allergy, Asthma, and Immunology Asthma Committee, credits the study for more clearly defining how the melatonin MT2 receptor plays a role in bronchoconstriction. “Our findings suggest, however, that pharmacological concentrations of melatonin would contribute to airway smooth-muscle contraction by the stimulation of melatonin MT2 receptor expressed on human airway smooth muscle, leading to bronchoconstriction, which could worsen asthma symptoms,” said Mizuta. Several mechanisms such as endogenous circadian rhythm disturbances, concomitant disorders, behavioral and environmental factors have been. It results in sleep depravation and impaired quality of life but is also associated with increased morbidity and mortality. Mizuta acknowledges that melatonin is often prescribed to people with insomnia, psychiatric disorders, cancers, or cardiovascular diseases not only because of its therapeutic effects but also due to it causing relatively few side effects. Nocturnal deterioration of lung function frequently occurs in asthma patients. Asthma is typically worse in the night and first thing in the morning although this can vary from a patient from the patient. It is important for consumers to know that some ‘natural’ remedies for sleep like melatonin can in fact pose a threat.” Excessive coughing or a cough that keeps you awake at night. “This research is important for patients as the use of over-the-counter supplements is rampant. With bronchial asthma, you may have one or more of the following signs and symptoms: Shortness of breath. “Previous research showed that melatonin might have some anti-inflammatory benefits and was a relatively safe supplement for patients,” said Payel Gupta, MD, a spokesperson for the American Lung Association, who was not involved in this study. Lab testing also revealed that melatonin also weakens the relaxing effect of a bronchodilator, a medicine which widens the bronchus. To relieve the constriction, people with asthma often use a bronchodilator, a medicine which widens the bronchus.
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